Lfng^tm1Seco
Targeted Allele Detail

Summary

• Symbol: Lfng^tm1Seco
• Name: LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase; targeted mutation 1, Susan E Cole
• MGI ID: MGI:3775061
• Synonyms: Lfng^deltaFCE1
• Gene: Lfng Location: Chr5:140593096-140601300 bp, + strand Genetic Position: Chr5, 79.15 cM
• Alliance: Lfng^tm1Seco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131837
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The fringe clock element 1 (FCE1) was removed and a neo-cre cassette was inserted downstream of exon 1. The neo/cre cassette was self-excised following passage through male germ cells. The absence of cycling transcript expression was confirmed by in situ hybridization. (J:131837)

Expression

In Mice Carrying this Mutation:	59 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lfng Mutation: 32 strains or lines available

References

• Original: J:131837 Shifley ET, et al., Oscillatory lunatic fringe activity is crucial for segmentation of the anterior but not posterior skeleton. Development. 2008 Mar;135(5):899-908
• All: 2 reference(s)