Ptrh2^tm1.1Eruo
Targeted Allele Detail

Summary

• Symbol: Ptrh2^tm1.1Eruo
• Name: peptidyl-tRNA hydrolase 2; targeted mutation 1.1, Erkki Ruoslahti
• MGI ID: MGI:3775076
• Synonyms: Bit1^-
• Gene: Ptrh2 Location: Chr11:86574900-86583283 bp, + strand Genetic Position: Chr11, 51.82 cM
• Alliance: Ptrh2^tm1.1Eruo page

Ptrh2^tm1.1Eruo/Ptrh2^tm1.1Eruo mice exhibit stunted growth after birth

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131853
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Germ-line cre-mediated recombination was used to remove the open reading frame. The absence of protein product was confirmed by western blot analysis on E14.5 embryo extracts. (J:131853)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptrh2 Mutation: 36 strains or lines available

References

• Original: J:131853 Kairouz-Wahbe R, et al., Anoikis effector Bit1 negatively regulates Erk activity. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1528-32
• All: 4 reference(s)