Rictor^{Gt(RRR347)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Rictor^{Gt(RRR347)Byg}
• Name: RPTOR independent companion of MTOR, complex 2; gene trap RRR347, BayGenomics
• MGI ID: MGI:3775093
• Synonyms: Rictor^-
• Gene: Rictor Location: Chr15:6737860-6829882 bp, + strand Genetic Position: Chr15, 3.25 cM, cytoband A1
• Alliance: Rictor^{Gt(RRR347)Byg} page

Mutation origin

• Mutant Cell Line: RRR347
• Germline Transmission: Earliest citation of germline transmission: J:113443
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT0Lxf Vector Type: gene trap
• Mutation details: A gene trap line was found to contain an insertional mutation in the third intron. The mutation results in the production of an in-frame fusion transcript consisting of exons 1-3 from Rictor (amino acids 1-65) and beta-geo. (J:113443)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRR347	CG784807 ; (MGI Seq Detail)	5' RACE	Chr15:6737861-6764940 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  43 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Mice Carrying this Mutation:	55 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rictor Mutation: 141 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:113443 Yang Q, et al., Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 2006 Oct 15;20(20):2820-32
• All: 6 reference(s)