Eya4^tm1Jse
Targeted Allele Detail

Summary

• Symbol: Eya4^tm1Jse
• Name: EYA transcriptional coactivator and phosphatase 4; targeted mutation 1, Jonathan G Seidman
• MGI ID: MGI:3775095
• Gene: Eya4 Location: Chr10:22978862-23226684 bp, - strand Genetic Position: Chr10, 10.44 cM
• Alliance: Eya4^tm1Jse page

Middle ear pathology shows that Eya4^tm1Jse/Eya4^tm1Jse mice develop otitis media

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131873
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 8 and all of exons 9 and 10 were replaced with a neo/zeocin cassette. The absence of transcript was confirmed by RT-PCR in cardiac extracts. (J:131873)

Disease models

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eya4 Mutation: 41 strains or lines available

References

• Original: J:131873 Depreux FF, et al., Eya4-deficient mice are a model for heritable otitis media. J Clin Invest. 2008 Feb;118(2):651-8
• All: 1 reference(s)