Hcn4^tm1Rsei
Targeted Allele Detail

Summary

• Symbol: Hcn4^tm1Rsei
• Name: hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1, Reinhart Seifert
• MGI ID: MGI:3775108
• Synonyms: HCN4^R699Q
• Gene: Hcn4 Location: Chr9:58730695-58770458 bp, + strand Genetic Position: Chr9, 31.8 cM, cytoband C
• Alliance: Hcn4^tm1Rsei page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131820
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A floxed neo cassette and an exon 7 containing a nucleotide substitution that resulted in a glutamine for arginine amino acid substitution at position 669 (R669Q) was knocked into the open reading frame. The neo cassette was removed by subsequent germ-line cre-mediated recombination. (J:131820)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hcn4 Mutation: 67 strains or lines available

References

• Original: J:131820 Harzheim D, et al., Cardiac pacemaker function of HCN4 channels in mice is confined to embryonic development and requires cyclic AMP. EMBO J. 2008 Feb 20;27(4):692-703
• All: 1 reference(s)