Phb2^tm1.1Tlan
Targeted Allele Detail

Summary

• Symbol: Phb2^tm1.1Tlan
• Name: prohibitin 2; targeted mutation 1.1, Thomas Langer
• MGI ID: MGI:3775183
• Gene: Phb2 Location: Chr6:124689299-124693913 bp, + strand Genetic Position: Chr6, 59.17 cM
• Alliance: Phb2^tm1.1Tlan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131699
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 3 and 4 were removed by germ-line cre-mediated recombination. The ability of this allele to function as a null allele was confirmed by western blot analysis on total lysates of cells carrying the floxed allele and transduced with cre, in which case no protein products were detected. (J:131699)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phb2 Mutation: 24 strains or lines available

References

• Original: J:131699 Merkwirth C, et al., Prohibitins control cell proliferation and apoptosis by regulating OPA1-dependent cristae morphogenesis in mitochondria. Genes Dev. 2008 Feb 15;22(4):476-88
• All: 1 reference(s)