Tg(KRT14-Angpt1)1Gdy
Transgene Detail

Summary

• Symbol: Tg(KRT14-Angpt1)1Gdy
• Name: transgene insertion 1, George D Yancopoulos
• MGI ID: MGI:3775303
• Synonyms: K14-Ang1
• Transgene: Tg(KRT14-Angpt1)1Gdy Location: unknown
• Alliance: Tg(KRT14-Angpt1)1Gdy page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT14-Angpt1)1Gdy expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Angpt1 (MGI:108448)

• Mutation details: This transgene consists of a 1.95 kb fragment containing the human keratin 14 promoter and enhancer sequences followed by a 1.7 kb cDNA containing the complete mouse angiopoietin 1 coding region and the human keratin 14 polyadenylation sequence. Transgenic mice overexpress angiopoietin 1 in the basal keratinocyte layer of the epidermis and in keratinocytes lining the hair follicles. (J:50482)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:50482 Suri C, et al., Increased vascularization in mice overexpressing angiopoietin-1. Science. 1998 Oct 16;282(5388):468-71
• All: 4 reference(s)