Myc^tm3(Tcrb)Fwa
Targeted Allele Detail

Summary

• Symbol: Myc^tm3(Tcrb)Fwa
• Name: myelocytomatosis oncogene; targeted mutation 3, Frederick W Alt
• MGI ID: MGI:3775386
• Synonyms: c-myc^Rep
• Gene: Myc Location: Chr15:61857240-61862223 bp, + strand Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
• Alliance: Myc^tm3(Tcrb)Fwa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131995
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutation: Insertion
• Mutation details: The gene locus was chosen due to its active transcription throughout T- and B- cell development. Germ-line Dbeta1 and Jbeta1.1 segments, their recombination signaling sequences and intervening intronic sequence were inserted between exon 1 and 2 of the gene locus. Southern blot analysis of T and B cells revealed germ-line and recombined versions of the knocked in gene segment. (J:131995)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Myc Mutation: 43 strains or lines available

References

• Original: J:131995 Ranganath S, et al., Productive coupling of accessible Vbeta14 segments and DJbeta complexes determines the frequency of Vbeta14 rearrangement. J Immunol. 2008 Feb 15;180(4):2339-46
• All: 2 reference(s)