Wwtr1^tm1Hku
Targeted Allele Detail

Summary

• Symbol: Wwtr1^tm1Hku
• Name: WW domain containing transcription regulator 1; targeted mutation 1, Hiroki Kurihara
• MGI ID: MGI:3775483
• Synonyms: Taz^lacZ
• Gene: Wwtr1 Location: Chr3:57363070-57483331 bp, - strand Genetic Position: Chr3, 27.74 cM
• Alliance: Wwtr1^tm1Hku page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132020
• Parent Cell Line: ATOM1 (ES Cell)
• Strain of Origin: (C57BL/6 x 129)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region in exon 2 was replaced with nls-lacZ/PGKneo cassette. The absence of transcripts and protein in homozygous mice was confirmed by RT-PCR and Western blotting. (J:132020)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Wwtr1 Mutation: 26 strains or lines available

References

• Original: J:132020 Makita R, et al., Multiple renal cysts, urinary concentration defects, and pulmonary emphysematous changes in mice lacking TAZ. Am J Physiol Renal Physiol. 2008 Mar;294(3):F542-53
• All: 5 reference(s)