Tmrdq1^BALB/cJ
QTL Variant Detail

Summary

• QTL variant: Tmrdq1^BALB/cJ
• Name: transmission ratio distortion QTL 1; BALB/cJ
• MGI ID: MGI:3775495
• QTL: Tmrdq1 Location: unknown Genetic Position: ChrX, Syntenic

Variant origin

• Strain of Specimen: BALB/cJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele is found in excess in non-cystic fibrosis female animals compared to C57BL/6J. (J:125558)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:125558

Previously mapped loci influencing survival in Cftr^tm1Unc mice on chromosomes 3, 5, and X were investigated using an expanded population of 1208 (C57BL/6-Cftr^tm1Unc x BALB/cJ)F2 animals. Of the 1208 F2 animals, 137 were homozygous for the Cftr^tm1Uncmutation, which is fewer than the 25% predicted for an autosomal recessive trait. Analysis of 186 F2 embryos at E15.5 revealed the expected Mendelian segregation ratios for Cftr^tm1Unc homozygous, heterozygous, and wild type genotypes. Authors conclude early lethality for Cftr1^tm1Unc homozygous animals occurs between E15.5 and 3-weeks post-weaning.

Female-specific transmission ratio distortion mapping to 37 cM on mouse Chromosome X was verified in this study. An excess of BALB/cJ alleles is observed at DXMit16 in 3-week old non-CF female F2 animals. This locus is named Tmrdq1 (transmission ratio distortion QTL 1). Potential candidate genes in this region include Arx (33.9 cM) and Nr0b1 (formerly Dax1, 33 cM).

Female-specific transmission ratio distortion was confirmed on mouse Chromosome 5 near D5Mit239 (58 cM). This locus is named Tmrdq2 (transmission ratio distortion QTL 2). An excess of BALB/cJ alleles is observed at Tmrd2 in 3-week old non-CF female F2 animals.

The chromosome 3 locus for transmission ratio distortion was not replicated in this study.

References

• Original: J:125558 Haston CK, et al., X chromosome transmission ratio distortion in Cftr +/- intercross-derived mice. BMC Genet. 2007;8:23
• All: 1 reference(s)