Esr1^tm1.2Mma
Targeted Allele Detail

Summary

• Symbol: Esr1^tm1.2Mma
• Name: estrogen receptor 1 (alpha); targeted mutation 1.2, Manuel Mark
• MGI ID: MGI:3775510
• Synonyms: ERalpha^flox, ERalpha^L2, Esr1^fl
• Gene: Esr1 Location: Chr10:4561989-4955633 bp, + strand Genetic Position: Chr10, 2.03 cM
• Alliance: Esr1^tm1.2Mma page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:64426
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The mutation is a derivative of Esr1^tm1Mma. The TK-neo cassette was deleted by Cre mediated recombination. In the resulting mice, exon 3 is flanked by loxP sites. (J:64426)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Esr1^tm1.2Mma/Esr1^tm1.2Mma Tg(Cga-cre)3Sac/0	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL
cn2	Esr1^tm1.2Mma/Esr1^tm1.2Mma Tg(Cyp17a1-icre)AJako/0	involves: 129S2/SvPas * C57BL/6 * SJL
cn3	Esr1^tm1.2Mma/Esr1^tm1.2Mma Tg(Wnt7a-EGFP/cre)#Bhr/0	involves: 129S2/SvPas * C57BL/6 * SJL

Phenotypes:

Affected Systems	cn1	cn2		cn3
show or hide all annotated terms Sex:
cardiovascular system		√
ovary hemorrhage		√
cellular		√
oocyte degeneration		√
endocrine/exocrine glands	√	√	√
ovary hemorrhage		√
increased gonadotroph cell number		√	√
abnormal ovary morphology		√
decreased corpora lutea number		√
abnormal ovarian follicle number		√
abnormal theca cell layer morphology		√
increased theca cell number		√
ovarian follicular cyst	√
hemorrhagic ovary cyst		√
growth/size/body	√	√
ovarian follicular cyst	√
hemorrhagic ovary cyst		√
homeostasis/metabolism		√	√
increased circulating testosterone level		√	√
decreased circulating luteinizing hormone level		√	√
mortality/aging		√	√
early reproductive senescence		√	√
nervous system		√	√
increased gonadotroph cell number		√	√
reproductive system	√	√	√	√
ovary hemorrhage		√
oocyte degeneration		√
abnormal ovary morphology		√
decreased corpora lutea number		√
abnormal ovarian follicle number		√
abnormal theca cell layer morphology		√
increased theca cell number		√
ovarian follicular cyst	√
hemorrhagic ovary cyst		√
early reproductive senescence		√	√
abnormal uterus morphology				√
abnormal uterus size				√
decreased superovulation rate		√
abnormal estrous cycle	√	√
prolonged diestrus		√
abnormal uterine receptivity				√
female infertility	√	√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Esr1^tm1.2Mma

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr1 Mutation: 68 strains or lines available

References

• Original: J:64426 Dupont S, et al., Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development. 2000 Oct;127(19):4277-91
• All: 51 reference(s)