Afg3l2^Emv66
Allele Detail

Summary

• Symbol: Afg3l2^Emv66
• Name: AFG3-like AAA ATPase 2; endogenous ecotropic MuLV 66
• MGI ID: MGI:3775617
• Gene: Afg3l2 Location: Chr18:67537834-67582242 bp, - strand Genetic Position: Chr18, 39.96 cM
• Alliance: Afg3l2^Emv66 page

Mutation origin

• Strain of Origin: MEV/2Ty-Afg3l2^Emv66

Mutation description

• Allele Type: Not Applicable (Null/knockout)
• Mutation: Viral insertion
• Mutation details: An ecotropic murine leukemia proviral reinsertion occurred within intron 14 of the gene. RT-PCR analysis on several tissues showed that no transcript containing sequences derived from exon 13-15 is expressed from this allele. An aberrant transcript contaning sequences upstream of the insertion site is detectable. Western blot analysis on tissue mitochondrial preparations shows that the protein product is not detectable in homozygous mice. (J:132285)
• Inheritance: Recessive

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Afg3l2 Mutation: 69 strains or lines available

References

• Original: J:132285 Maltecca F, et al., The mitochondrial protease AFG3L2 is essential for axonal development. J Neurosci. 2008 Mar 12;28(11):2827-36
• All: 8 reference(s)