Ifnlr1^tm1Palu
Targeted Allele Detail

Summary

• Symbol: Ifnlr1^tm1Palu
• Name: interferon lambda receptor 1; targeted mutation 1, Soren R Paludan
• MGI ID: MGI:3775762
• Synonyms: IL-28RA^-
• Gene: Ifnlr1 Location: Chr4:135413598-135435492 bp, + strand Genetic Position: Chr4, 67.94 cM
• Alliance: Ifnlr1^tm1Palu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:131989
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region including the 7 coding exons, 6 introns, and the first 219-bp of 3' untranslated region of the mouse Il28ra gene was replaced with an IRES-LacZ/MC1-Neo cassette by homologous recombination in ES cells. The real-time RT-PCR confirmed absence of expression. (J:131989)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ifnlr1 Mutation: 37 strains or lines available

References

• Original: J:131989 Ank N, et al., An important role for type III Interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity. J Immunol. 2008 Feb 15;180(4):2474-85
• All: 42 reference(s)