Cops5^tm1Rpar
Targeted Allele Detail

Summary

• Symbol: Cops5^tm1Rpar
• Name: COP9 signalosome subunit 5; targeted mutation 1, Ruggero Pardi
• MGI ID: MGI:3775801
• Synonyms: Cops5^flox, CSN5^fl, CSN5/JAB1^flox, Jab1^fl
• Gene: Cops5 Location: Chr1:10094825-10108384 bp, - strand Genetic Position: Chr1, 2.29 cM
• Alliance: Cops5^tm1Rpar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132114
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: An frt-flanked neo cassette with a 5' loxP site was inserted downstream of exon 2 and an additional loxP site was inserted upstream of exon 2. Germ-line, flp-mediated recombination was used to remove the neo cassette leaving a floxed exon 2. (J:132114)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cops5 Mutation: 25 strains or lines available

References

• Original: J:132114 Panattoni M, et al., Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development. J Exp Med. 2008 Feb 18;205(2):465-77
• All: 12 reference(s)