Slc4a7^{Gt(RRL021)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Slc4a7^{Gt(RRL021)Byg}
• Name: solute carrier family 4, sodium bicarbonate cotransporter, member 7; gene trap RRL021, BayGenomics
• MGI ID: MGI:3775809
• Synonyms: NBCn1^LacZ
• Gene: Slc4a7 Location: Chr14:7669819-7766808 bp, - strand Genetic Position: Chr14, 7.08 cM
• Alliance: Slc4a7^{Gt(RRL021)Byg} page

Mutation origin

• Mutant Cell Line: RRL021
• Germline Transmission: Earliest citation of germline transmission: J:132199
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT2Lxf Vector Type: gene trap
• Mutation details: The gene trap vector was inserted between exons 3 and 4. Transcript levels are reduced 54% and protein levels 72% in homozygous mice. This is a hypomorphic allele. (J:132199)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  RRL021	CG785058 ; (MGI Seq Detail)	5' RACE	Chr14:7735895-7766560 bp (-)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  11 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slc4a7 Mutation: 76 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:132199 Boedtkjer E, et al., Antibody-independent localization of the electroneutral Na+-HCO3- cotransporter NBCn1 (slc4a7) in mice. Am J Physiol Cell Physiol. 2008 Feb;294(2):C591-603
• All: 2 reference(s)