Nlgn4l^{Gt(XST093)Byg}
Gene trapped Allele Detail

Summary

• Symbol: Nlgn4l^{Gt(XST093)Byg}
• Name: neuroligin 4-like; gene trap XST093, BayGenomics
• MGI ID: MGI:3775814
• Synonyms: NL-4-KO, Nlgn3^-, XST093^{Gt(pGT1TMpfs)1Ucd}
• Gene: Nlgn4l Location: ChrX:169067543-169089017 bp, - strand
• Alliance: Nlgn4l^{Gt(XST093)Byg} page

Decrease of brain volume in Nlgn4l^{Gt(XST093)Byg}/Nlgn4l^{Gt(XST093)Byg} mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Mutant Cell Line: XST093
• Germline Transmission: Earliest citation of germline transmission: J:131843
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector Vector: pGT1TMpfs Vector Type: secretory trap
• Mutation details: The gene trap vector was inserted 340 bp downstream of the first exon. LacZ expression was confirmed by beta-galactosidase assay. The fusion protein produced by this allele is nonfuctional because it only possesses a small portion of the esterase domain and cannot bind neurexins. This is a null allele. (J:131843)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XST093	CC156419 ; (MGI Seq Detail)	5' RACE	unknown
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  1 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nlgn4l Mutation: 1 strain or line available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:131843 Jamain S, et al., Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1710-5
• All: 19 reference(s)