Pdpn^tm1Acgg
Targeted Allele Detail

Summary

• Symbol: Pdpn^tm1Acgg
• Name: podoplanin; targeted mutation 1, Adriana C Gittenberger-De Groot
• MGI ID: MGI:3775822
• Gene: Pdpn Location: Chr4:142994001-143026134 bp, - strand Genetic Position: Chr4, 77.29 cM
• Alliance: Pdpn^tm1Acgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132132
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 through 4 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on E13.5 whole embryo extracts. (J:132132)

Expression

In Mice Carrying this Mutation:	48 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdpn Mutation: 29 strains or lines available

References

• Original: J:132132 Mahtab EA, et al., Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development. Dev Dyn. 2008 Mar;237(3):847-57
• All: 7 reference(s)