Sp6^tm1Yoya
Targeted Allele Detail

Summary

• Symbol: Sp6^tm1Yoya
• Name: trans-acting transcription factor 6; targeted mutation 1, Yoshihiko Yamada
• MGI ID: MGI:3775913
• Synonyms: Epfn^-
• Gene: Sp6 Location: Chr11:96904395-96915565 bp, + strand Genetic Position: Chr11, 60.51 cM
• Alliance: Sp6^tm1Yoya page

Defective tooth formation in Sp6^tm1Yoya/Sp6^tm1Yoya mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132157
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Exon 2, which contains the entire coding region, was replaced by a neo cassette. (J:132157)

Expression

In Mice Carrying this Mutation:	63 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sp6 Mutation: 18 strains or lines available

References

• Original: J:132157 Nakamura T, et al., Transcription factor epiprofin is essential for tooth morphogenesis by regulating epithelial cell fate and tooth number. J Biol Chem. 2008 Feb 22;283(8):4825-33
• All: 7 reference(s)