Esr2^tm1.2Pcn
Targeted Allele Detail

Summary

• Symbol: Esr2^tm1.2Pcn
• Name: estrogen receptor 2 (beta); targeted mutation 1.2, Pierre Chambon
• MGI ID: MGI:3775925
• Synonyms: ERbetaST^L-
• Gene: Esr2 Location: Chr12:76167193-76224033 bp, - strand Genetic Position: Chr12, 33.52 cM, cytoband D1-D3
• Alliance: Esr2^tm1.2Pcn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132171
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The neo cassette and exon 3 were removed by germ-line, cre-mediated recombination. The absence of protein product was confirmed by western blot analysis on testis and prostate tissue extracts. (J:132171)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Esr2 Mutation: 36 strains or lines available

References

• Original: J:132171 Antal MC, et al., Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERbeta-null mutant. Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2433-8
• All: 3 reference(s)