S100a1^tm1Mfs
Targeted Allele Detail

Summary

• Symbol: S100a1^tm1Mfs
• Name: S100 calcium binding protein A1; targeted mutation 1, Martin Schneider
• MGI ID: MGI:3775945
• Synonyms: S100A1^LacZ
• Gene: S100a1 Location: Chr3:90418341-90421637 bp, - strand Genetic Position: Chr3, 39.24 cM, cytoband F1-F2
• Alliance: S100a1^tm1Mfs page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132177
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene with a nuclear localization signal and a neo cassette was inserted in frame at the A8 codon in exon 2. The absence of protein product was confirmed by immunohistochemistry on muscle fibers. This is a null allele. (J:132177)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any S100a1 Mutation: 12 strains or lines available

References

• Original: J:132177 Prosser BL, et al., S100A1 binds to the calmodulin-binding site of ryanodine receptor and modulates skeletal muscle excitation-contraction coupling. J Biol Chem. 2008 Feb 22;283(8):5046-57
• All: 3 reference(s)