Sox10^Dal
Chemically induced Allele Detail

Summary

• Symbol: Sox10^Dal
• Name: SRY (sex determining region Y)-box 10; dalmatian
• MGI ID: MGI:3775949
• Synonyms: Sox10^M1Btlr
• Gene: Sox10 Location: Chr15:79039113-79048690 bp, - strand Genetic Position: Chr15, 37.7 cM
• Alliance: Sox10^Dal page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutaion is a T-to-G transversion at nucleotide position 676 of the gene (Genbank: XM_128139), in the second exon. It results in replacement of asparagine by lysine at amino acid position 131 (N131K), the terminal amino acid of the loop between the first and second alpha-helices (sometimes considered the first aa of helix II) in the DNA-binding HMG domain of the protein. (J:132358)
• Inheritance: Dominant

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Sox10 Mutation: 33 strains or lines available

References

• Original: J:132358 Smart NG, et al., Dalmatian, a mouse white spotting coat color mutant allele of Sox10. MGI Direct Data Submission. 2008
• All: 1 reference(s)