Gja1^tm8.1Kwi
Targeted Allele Detail

Summary

• Symbol: Gja1^tm8.1Kwi
• Name: gap junction protein, alpha 1; targeted mutation 8.1, Klaus Willecke
• MGI ID: MGI:3776014
• Synonyms: Cx43^G138R
• Gene: Gja1 Location: Chr10:56253297-56266519 bp, + strand Genetic Position: Chr10, 28.64 cM
• Alliance: Gja1^tm8.1Kwi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132032
• Parent Cell Line: HM-1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd-Hprt1^b-m3

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion, Nucleotide substitutions
• Mutation details: Germ-line, cre-mediated recombantion was used to remove the wild-type locus and the neo cassette that resulted in the expression of the modified locus and IRES-eGFP cassette. (J:132032)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gja1 Mutation: 60 strains or lines available

References

• Original: J:132032 Dobrowolski R, et al., The conditional connexin43G138R mouse mutant represents a new model of hereditary oculodentodigital dysplasia in humans. Hum Mol Genet. 2008 Feb 15;17(4):539-54
• All: 1 reference(s)