Efemp1^tm2Lmar
Targeted Allele Detail

Summary

• Symbol: Efemp1^tm2Lmar
• Name: epidermal growth factor-containing fibulin-like extracellular matrix protein 1; targeted mutation 2, Lihua Y Marmorstein
• MGI ID: MGI:3776015
• Gene: Efemp1 Location: Chr11:28803204-28876743 bp, + strand Genetic Position: Chr11, 16.32 cM, cytoband A4
• Alliance: Efemp1^tm2Lmar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132043
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 4 and 5 were replaced with a floxed neo cassette. The absence of protein product was confirmed by western blot analysis on lung extracts. (J:132043)

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Efemp1 Mutation: 36 strains or lines available

References

• Original: J:132043 McLaughlin PJ, et al., Lack of fibulin-3 causes early aging and herniation, but not macular degeneration in mice. Hum Mol Genet. 2007 Dec 15;16(24):3059-70
• All: 5 reference(s)