Flvcr1^tm1Jlab
Targeted Allele Detail

Summary

• Symbol: Flvcr1^tm1Jlab
• Name: feline leukemia virus subgroup C cellular receptor 1; targeted mutation 1, Janis L Abkowitz
• MGI ID: MGI:3776021
• Synonyms: Flvcr^flox
• Gene: Flvcr1 Location: Chr1:190738044-190758355 bp, - strand Genetic Position: Chr1, 96.28 cM
• Alliance: Flvcr1^tm1Jlab page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132057
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted downstream of exon 1 and an additional loxP site was inserted upstream of exon 3. The neo cassette was removed by transient cre-mediated recombination to leave a floxed exon 3. (J:132057)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flvcr1 Mutation: 32 strains or lines available

References

• Original: J:132057 Keel SB, et al., A heme export protein is required for red blood cell differentiation and iron homeostasis. Science. 2008 Feb 8;319(5864):825-8
• All: 5 reference(s)