Gt(ROSA)26Sor^tm1(ptxA)Cgh
Targeted Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^tm1(ptxA)Cgh
• Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Shaun R Coughlin
• MGI ID: MGI:3776029
• Synonyms: ROSA26^PTX
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^tm1(ptxA)Cgh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:130781
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A splice acceptor, floxed neo cassette and ptxA (pertussis toxin subunit 1) were knocked into intron 1. Removal of the neo cassette by cre-mediated recombination will result in the expresson of ptxA. (J:130781)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 992 strains or lines available

References

• Original: J:130781 Regard JB, et al., Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest. 2007 Dec;117(12):4034-43
• All: 15 reference(s)