Ldha^a-m2Neu
Chemically induced Allele Detail

Summary

• Symbol: Ldha^a-m2Neu
• Name: lactate dehydrogenase A; mutation 2, Neuherberg
• MGI ID: MGI:3776262
• Synonyms: LDH 1049, Ldh1^a2Neu
• Gene: Ldha Location: Chr7:46491698-46505051 bp, + strand Genetic Position: Chr7, 30.6 cM
• Alliance: Ldha^a-m2Neu page

Mutation origin

• Strain of Origin: (102/El x C3H/El)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU mutagenesis resulted in a nucleotide substitution at codon 112 of AAC to GAC that created an amino acid substitution of an aspartic acid for an asparagine at position 112 (N112D). This mutation occures in the coenzyme-binding domain and results in a decreased enzymatic activity to 58% of wild-type in heterozygotes. (J:45877)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldha Mutation: 35 strains or lines available

References

• Original: J:15477 Charles DJ, et al., Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice. Mutat Res. 1987 Jan;176(1):81-91
• All: 4 reference(s)