Ldha^a-m5Neu
Chemically induced Allele Detail

Summary

• Symbol: Ldha^a-m5Neu
• Name: lactate dehydrogenase A; mutation 5, Neuherberg
• MGI ID: MGI:3776265
• Synonyms: LDH 1623, Ldh1^a5Neu
• Gene: Ldha Location: Chr7:46491698-46505051 bp, + strand Genetic Position: Chr7, 30.6 cM
• Alliance: Ldha^a-m5Neu page

Mutation origin

• Strain of Origin: (102/El x C3H/El)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU-mutagenesis resulted in a transition of A to G at codon 216 that caused an amino acid substitution of a glycine for a glutamic acid at position 216 (E216G). Enzyme activity is 85% of wild-type in homozygous mice. (J:22177)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldha Mutation: 35 strains or lines available

References

• Original: J:506 Merkle S, et al., Characterization of two electrophoretic lactate dehydrogenase-A mutants in Mus musculus. Biochem Genet. 1992 Feb;30(1-2):49-59
• All: 4 reference(s)