Ldha^a-m6Neu
Chemically induced Allele Detail

Summary

• Symbol: Ldha^a-m6Neu
• Name: lactate dehydrogenase A; mutation 6, Neuherberg
• MGI ID: MGI:3776266
• Synonyms: LDH 10866, Ldh1^a6Neu
• Gene: Ldha Location: Chr7:46491698-46505051 bp, + strand Genetic Position: Chr7, 30.6 cM
• Alliance: Ldha^a-m6Neu page

Mutation origin

• Strain of Origin: (102/El x C3H/El)F1

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: ENU-mutagenesis resulted in a transition of A to G at codon 225 that caused an amino acid substitution of an arginine for a glutamine at position 225 (Q225R). Enzyme activity is 100% of wild-type. (J:22177)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldha Mutation: 35 strains or lines available

References

• Original: J:7771 Charles DJ, et al., A new pyruvate kinase mutation with hyperactivity in the mouse. Biochem Genet. 1984 Dec;22(11-12):1103-17
• All: 5 reference(s)