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Ldhaa-m7Neu
Chemically induced Allele Detail
Summary
Symbol: Ldhaa-m7Neu
Name: lactate dehydrogenase A; mutation 7, Neuherberg
MGI ID: MGI:3776295
Synonyms: Ldh17Neu, LDH 1962, Ldh1a7Neu
Gene: Ldha  Location: Chr7:46491698-46505051 bp, + strand  Genetic Position: Chr7, 30.6 cM
Alliance: Ldhaa-m7Neu page
Mutation
origin
Strain of Origin:  (102/El x C3H/El)F1
Mutation
description
Allele Type:    Chemically induced (ENU)
Mutation:    Single point mutation
 
Mutation detailsENU-mutagenesis resulted in a transition at codon 194 (GAC to GCC) that caused an amino acid substitution of alanine for aspartic acid at position 194 (D194A). Enzyme activity is reduced to 63% of wild-type in heterozygotes and 24% of wild-type in ho0mozygotes. (J:45877)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ldha Mutation:  35 strains or lines available
References
Original:  J:15477 Charles DJ, et al., Linear dose-response relationship of erythrocyte enzyme-activity mutations in offspring of ethylnitrosourea-treated mice. Mutat Res. 1987 Jan;176(1):81-91
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/22/2024
MGI 6.24
The Jackson Laboratory