Ldha^a-m12Neu
Radiation induced Allele Detail

Summary

• Symbol: Ldha^a-m12Neu
• Name: lactate dehydrogenase A; mutation 12, Neuherberg
• MGI ID: MGI:3776296
• Synonyms: LDH 144, Ldh1^a12Neu
• Gene: Ldha Location: Chr7:46491698-46505051 bp, + strand Genetic Position: Chr7, 30.6 cM
• Alliance: Ldha^a-m12Neu page

Mutation origin

• Strain of Origin: C3H/El

Mutation description

• Allele Type: Radiation induced
• Mutation: Single point mutation
• Mutation details: Gamme radiation-induced mutagenesis resulted in a transition in codon 241 (ATC to ACC) that caused an amino acid substitution of threonine for isoleucine at position 241 (I241T). Enzyme activity is reduced to 59% of wild-type in heterozygotes and 29% of wild-type in homozygotes. (J:45877)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldha Mutation: 35 strains or lines available

References

• Original: J:45877 Pretsch W, et al., Molecular, genetic and biochemical characterization of lactate dehydrogenase-A enzyme activity mutations in Mus musculus. Mamm Genome. 1998 Feb;9(2):144-9
• All: 1 reference(s)