Ldha^a-m11Neu
Radiation induced Allele Detail

Summary

• Symbol: Ldha^a-m11Neu
• Name: lactate dehydrogenase A; mutation 11, Neuherberg
• MGI ID: MGI:3776298
• Synonyms: Ldh1^a11Neu, LDH 215
• Gene: Ldha Location: Chr7:46491698-46505051 bp, + strand Genetic Position: Chr7, 30.6 cM
• Alliance: Ldha^a-m11Neu page

Mutation origin

• Strain of Origin: C3H/El

Mutation description

• Allele Type: Radiation induced
• Mutation: Single point mutation
• Mutation details: Radiation-induced mutagenesis resulted in 2 transitions and 1 transversion at condon 318 (AGC to AGT), codon 319 (GCA to GAA) and codon 321 (ACC to AGC) that caused amino acid substitutions of glutamic acid for alanine at position 319 (A319E) and serine for threonine at position 321 (S321T). The transition at codon 318 is silent. Enzyme activity is decreased to 61% of wild-type in heterozygotes and 18% of wild-type in homozygotes. (J:45877)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ldha Mutation: 35 strains or lines available

References

• Original: J:45877 Pretsch W, et al., Molecular, genetic and biochemical characterization of lactate dehydrogenase-A enzyme activity mutations in Mus musculus. Mamm Genome. 1998 Feb;9(2):144-9
• All: 1 reference(s)