Tg(Igh3H9)41Mwg
Transgene Detail

Summary

• Symbol: Tg(Igh3H9)41Mwg
• Name: transgene insertion 41, Martin Weigert
• MGI ID: MGI:3776392
• Synonyms: Tg(Igh-6*3H9)41Tnm, VH3H9
• Transgene: Tg(Igh3H9)41Mwg Location: unknown
• Alliance: Tg(Igh3H9)41Mwg page

Transgene origin

• Strain of Origin: (C57BL/6 x SJL)F1

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Igh3H9)41Mwg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Igh (MGI:96442)

• Mutation details: The rearranged heavy chain VDJ gene segments and the IgM constant domain were isolated from the murine B cell clone 3H9. Transgenic mice were generated and expression of the transgene confirmed by primer extension analysis of spleen RNA. The heavy chain expressed by this transgene is able to heterodimerize with endogenous Ig light chains to produce IgM antibodies that have a high affinity for DNA similar to the antibody produced by the 3H9 clone. (J:119625)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:119625 Erikson J, et al., Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature. 1991 Jan 24;349(6307):331-4
• All: 11 reference(s)