Dll1^tm2Gos
Targeted Allele Detail

Summary

• Symbol: Dll1^tm2Gos
• Name: delta like canonical Notch ligand 1; targeted mutation 2, Achim Gossler
• MGI ID: MGI:3776424
• Synonyms: Dll1^Dll1kineo, Dll1^Dll1wtki, Dll1^hyp, Dll1^KI
• Gene: Dll1 Location: Chr17:15587616-15597134 bp, - strand Genetic Position: Chr17, 8.95 cM
• Alliance: Dll1^tm2Gos page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132241
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A full-length Dll1 cDNA and a floxed neo cassette were inserted downstream of exon 1. This is a hypomorphic allele. Removal of the neo cassette restores normal function to this gene. (J:119082, J:132241)

Expression

In Mice Carrying this Mutation:	164 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dll1 Mutation: 46 strains or lines available

References

• Original: J:132241 Kiernan AE, et al., The Notch ligands DLL1 and JAG2 act synergistically to regulate hair cell development in the mammalian inner ear. Development. 2005 Oct;132(19):4353-62
• All: 8 reference(s)