Il2rg^tm2Cgn
Targeted Allele Detail

Summary

• Symbol: Il2rg^tm2Cgn
• Name: interleukin 2 receptor, gamma chain; targeted mutation 2, University of Cologne
• MGI ID: MGI:3776426
• Synonyms: Il2rg^flox
• Gene: Il2rg Location: ChrX:100307991-100311861 bp, - strand Genetic Position: ChrX, 43.9 cM
• Alliance: Il2rg^tm2Cgn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:22521
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into intron 1 and a loxP-flanked neomycin resistance cassette was placed into intron 6. After transient expression of Cre recombinase, ES cells with deletion of just the neo cassette were selected. Mice derived from these cells have loxP sites flanking exons 2 through 6, which encode the extracellular and transmembrane domains of the protein (J:22521)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Il2rg Mutation: 179 strains or lines available

References

• Original: J:22521 DiSanto JP, et al., Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A. 1995 Jan 17;92(2):377-81
• All: 4 reference(s)