Ahr^tm1(AHR)Mym
Targeted Allele Detail

Summary

• Symbol: Ahr^tm1(AHR)Mym
• Name: aryl-hydrocarbon receptor; targeted mutation 1, Masayuki Yamamoto
• MGI ID: MGI:3776466
• Gene: Ahr Location: Chr12:35547978-35584988 bp, - strand Genetic Position: Chr12, 15.78 cM
• Alliance: Ahr^tm1(AHR)Mym page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132380
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Ahr^tm1(AHR)Mym expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  AHR (196)

  Ahr	(MGI:105043)

• Mutation details: Exon 1 and part of the subsequent intron were replaced with the coding region of human Ahr and a neo cassette. Expression of the human gene was confirmed by immunohistochemistry of lung tissue. (J:132380)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ahr Mutation: 112 strains or lines available

References

• Original: J:132380 Moriguchi T, et al., Distinct response to dioxin in an arylhydrocarbon receptor (AHR)-humanized mouse. Proc Natl Acad Sci U S A. 2003 May 13;100(10):5652-7
• All: 1 reference(s)