Cd3e^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Cd3e^m1Btlr
• Name: CD3 antigen, epsilon polypeptide; mutation 1, Bruce Beutler
• MGI ID: MGI:3776477
• Synonyms: tumormouse
• Gene: Cd3e Location: Chr9:44910038-44920925 bp, - strand Genetic Position: Chr9, 24.84 cM
• Alliance: Cd3e^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: The mutation is a C-to-A transversion at nucleotide position 330 (Genbank Accession NM_007648), replacing the codon for tyrosine at amino acid position 84, in the intracellular domain, with a premature termination codon (Y84Ter). (J:132486)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd3e Mutation: 54 strains or lines available

References

• Original: J:132486 Du X, et al., Tumormouse, an ENU-induced mutant model for human immunodeficiency due to defect in CD3-epsilon. MGI Direct Data Submission. 2008
• All: 3 reference(s)