Slamf1^tm1Oono
Targeted Allele Detail

Summary

• Symbol: Slamf1^tm1Oono
• Name: signaling lymphocytic activation molecule family member 1; targeted mutation 1, Shinji Ohno
• MGI ID: MGI:3776761
• Synonyms: SLAM Knock-in
• Gene: Slamf1 Location: Chr1:171594700-171628752 bp, + strand Genetic Position: Chr1, 79.54 cM
• Alliance: Slamf1^tm1Oono page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117810
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The loxP flanked neomycin cassette was introduced between exon 1 and 2, then exon 2 encoding the V domain was replaced with the corresponding human sequence. The neo cassette was later excised by cre recombinase expressing transgenic mice. Human SLAM V domain specific MAb confirmed expression of human/mouse chimeric SLAM protein in thymocytes. (J:117810)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Slamf1 Mutation: 24 strains or lines available

References

• Original: J:117810 Ohno S, et al., Measles virus infection of SLAM (CD150) knockin mice reproduces tropism and immunosuppression in human infection. J Virol. 2007 Feb;81(4):1650-9
• All: 3 reference(s)