Tg(Lck-Stat5b*)1Mafa
Transgene Detail
|
|
| Symbol: |
Tg(Lck-Stat5b*)1Mafa |
| Name: |
transgene insertion 1, Michael A Farrar |
| MGI ID: |
MGI:3776805 |
| Synonyms: |
CA-STAT5, STAT5b-CA |
| Transgene: |
Tg(Lck-Stat5b*)1Mafa Location: unknown
|
| Alliance: |
Tg(Lck-Stat5b*)1Mafa page
|
|
| Strain of Origin: |
Not Applicable
|
|
| Transgene Type: |
|
Transgenic (Constitutively active, Inserted expressed sequence) |
| Mutation: |
|
Insertion
|
| |
|
Mutation details: The Lck promoter with the Emu enhancer drives expression of a cDNA encoding a constitutively active Stat5b with point mutations that result in replacement of histidine with arginine at position 299 and serine with phenylalanine at position 711. This mutation results in constitutive phosphorylation of tyrosine 699.
(J:86610)
|
|
|
View phenotypes and curated references for all genotypes (concatenated display).
|
| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
|
|
| Original: |
J:86610 Burchill MA, et al., Distinct effects of STAT5 activation on CD4+ and CD8+ T cell homeostasis: development of CD4+CD25+ regulatory T cells versus CD8+ memory T cells. J Immunol. 2003 Dec 1;171(11):5853-64 |
| All: |
31 reference(s) |
|
Analysis Tools
