Zbp1^tm1Aki
Targeted Allele Detail

Summary

• Symbol: Zbp1^tm1Aki
• Name: Z-DNA binding protein 1; targeted mutation 1, Shizuo Akira
• MGI ID: MGI:3776827
• Synonyms: DAI^-
• Gene: Zbp1 Location: Chr2:173048405-173060715 bp, - strand Genetic Position: Chr2, 95.83 cM, cytoband H3
• Alliance: Zbp1^tm1Aki page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132662
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of exon 2 and all of exon 3 were replaced with a neomycin resistance cassette. A lack of gene expression was confirmed by northern blot analysis of embryonic fibroblasts isolated from homozygotes. (J:132662)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbp1 Mutation: 29 strains or lines available

References

• Original: J:132662 Ishii KJ, et al., TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines. Nature. 2008 Feb 7;451(7179):725-9
• All: 31 reference(s)