Hdac6^tm1.1Pmt
Targeted Allele Detail

Summary

• Symbol: Hdac6^tm1.1Pmt
• Name: histone deacetylase 6; targeted mutation 1.1, Patrick Matthias
• MGI ID: MGI:3776868
• Gene: Hdac6 Location: ChrX:7796359-7814128 bp, - strand Genetic Position: ChrX, 3.58 cM
• Alliance: Hdac6^tm1.1Pmt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132629
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 8, 9 and 10 were removed by transient cre expression in ES cells. The absence of protein product was confirmed by western blot analysis on brain, heart, kidney, liver, spleen and testis extracts. (J:132629)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac6 Mutation: 17 strains or lines available

References

• Original: J:125219 Boyault C, et al., HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. Genes Dev. 2007 Sep 1;21(17):2172-81
• All: 25 reference(s)