Egln2^tm1Pec
Targeted Allele Detail

Summary

• Symbol: Egln2^tm1Pec
• Name: egl-9 family hypoxia-inducible factor 2; targeted mutation 1, Peter Carmeliet
• MGI ID: MGI:3776872
• Synonyms: Phd1^-
• Gene: Egln2 Location: Chr7:26858083-26866227 bp, - strand Genetic Position: Chr7, 15.83 cM
• Alliance: Egln2^tm1Pec page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132630
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on mouse embryonic fibroblast extracts. (J:132630)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egln2 Mutation: 18 strains or lines available

References

• Original: J:132630 Aragones J, et al., Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism. Nat Genet. 2008 Feb;40(2):170-80
• All: 14 reference(s)