Rtl1^tm1Fuis
Targeted Allele Detail

Summary

• Symbol: Rtl1^tm1Fuis
• Name: retrotransposon Gaglike 1; targeted mutation 1, Fumitoshi Ishino
• MGI ID: MGI:3776873
• Gene: Rtl1 Location: Chr12:109555627-109566764 bp, - strand Genetic Position: Chr12, 60.38 cM
• Alliance: Rtl1^tm1Fuis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132647
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame was replaced with a neo cassette that was subsequently removed by transient cre expression. The absence of transcript expression was confirmed by RT-PCR. This allele also results in the deletion of 6 of the up to 7 microRNAs located within the anti-sense strand of the gene, which include: Mirn127, Mirn136, Mirn431, Mirn433 (5' and 3') and Mirn434 (5' and 3'). (J:132647)

Expression

In Mice Carrying this Mutation:	62 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rtl1 Mutation: 78 strains or lines available

References

• Original: J:132647 Sekita Y, et al., Role of retrotransposon-derived imprinted gene, Rtl1, in the feto-maternal interface of mouse placenta. Nat Genet. 2008 Feb;40(2):243-8
• All: 4 reference(s)