Tjp2^tm1Whun
Targeted Allele Detail

Summary

• Symbol: Tjp2^tm1Whun
• Name: tight junction protein 2; targeted mutation 1, Walter Hunziker
• MGI ID: MGI:3776874
• Synonyms: ZO-2^-
• Gene: Tjp2 Location: Chr19:24071869-24202394 bp, - strand Genetic Position: Chr19, 19.17 cM, cytoband C1
• Alliance: Tjp2^tm1Whun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132649
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ cassette and floxed neo cassette were inserted into exon 2 following the translation initiation site. The absence of protein product was confirmed by western blot analysis and immunofluorescence. (J:132649)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tjp2 Mutation: 88 strains or lines available

References

• Original: J:132649 Xu J, et al., Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development. Mol Cell Biol. 2008 Mar;28(5):1669-78
• All: 2 reference(s)