Tjp3^tm1Whun
Targeted Allele Detail

Summary

• Symbol: Tjp3^tm1Whun
• Name: tight junction protein 3; targeted mutation 1, Walter Hunziker
• MGI ID: MGI:3776875
• Synonyms: ZO-3^-
• Gene: Tjp3 Location: Chr10:81109041-81127415 bp, - strand Genetic Position: Chr10, 39.72 cM, cytoband C1
• Alliance: Tjp3^tm1Whun page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132649
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ cassette and floxed neo cassetted were inserted into exon 2 following the translation initiation site. The absence of protein product was confirmed by western blot analysis on intestine and liver extracts. (J:132649)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tjp3 Mutation: 35 strains or lines available

References

• Original: J:132649 Xu J, et al., Early embryonic lethality of mice lacking ZO-2, but Not ZO-3, reveals critical and nonredundant roles for individual zonula occludens proteins in mammalian development. Mol Cell Biol. 2008 Mar;28(5):1669-78
• All: 1 reference(s)