Hprt1^tm2Brd
Targeted Allele Detail

Summary

• Symbol: Hprt1^tm2Brd
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Allan Bradley
• MGI ID: MGI:3776895
• Synonyms: hprt^(Myo7a)Brd, hprt^{(Myo7a-lacZ)Brd}
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^tm2Brd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132633
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: Using RMCE the BAC RPCI 23-138G2 was inserted into the RMCE ready locus of Hprt^tm1Brd. This BAC is 219 kb in length and contains a modified Myo7a with a lacZ and frt-flanked neo cassette inserted upstream of the coding region. (J:132633)

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)
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cx1	Hprt1^tm2Brd/Hprt1^+ Myo7a^4626SB/Myo7a^4626SB	involves: 129S7/SvEvBrd * BALB/cRl * C3H * C57BL/6J * CBA/Ca

Phenotypes:

Affected Systems	cx1
show or hide all annotated terms Sex:
hearing/vestibular/ear	N
hearing/vestibular/ear phenotype	N

View phenotypes and curated references for all genotypes (concatenated display).

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1281 strains or lines available

References

• Original: J:132633 Prosser HM, et al., Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell Biol. 2008 Mar;28(5):1702-12
• All: 2 reference(s)