Hprt1tm2Brd
Targeted Allele Detail
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Symbol: |
Hprt1tm2Brd |
Name: |
hypoxanthine phosphoribosyltransferase 1; targeted mutation 2, Allan Bradley |
MGI ID: |
MGI:3776895 |
Synonyms: |
hprt(Myo7a)Brd, hprt(Myo7a-lacZ)Brd |
Gene: |
Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
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Alliance: |
Hprt1tm2Brd page
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Germline Transmission: |
Earliest citation of germline transmission:
J:132633
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Parent Cell Line: |
AB1 (ES Cell)
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Strain of Origin: |
129S7/SvEvBrd-Hprt1+
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Allele Type: |
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Targeted (Null/knockout, Reporter) |
Mutation: |
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Insertion
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Mutation details: Using RMCE the BAC RPCI 23-138G2 was inserted into the RMCE ready locus of Hprttm1Brd. This BAC is 219 kb in length and contains a modified Myo7a with a lacZ and frt-flanked neo cassette inserted upstream of the coding region.
(J:132633)
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Key: |
hm |
homozygous |
ht |
heterozygous |
tg |
involves transgenes |
√ |
phenotype observed |
cn |
conditional genotype |
cx |
complex: > 1 genome feature |
ot |
other: hemizygous, indeterminate,... |
N |
normal phenotype |
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Genotype/ Background: |
| Allelic Composition | Genetic Background | Cell Line(s) |
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Loading... | | | involves: 129S7/SvEvBrd * BALB/cRl * C3H * C57BL/6J * CBA/Ca | |
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Phenotypes: |
Affected Systems |
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hearing/vestibular/ear
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N
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hearing/vestibular/ear phenotype
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N
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View phenotypes and curated references for all genotypes (concatenated display).
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Original: |
J:132633 Prosser HM, et al., Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia. Mol Cell Biol. 2008 Mar;28(5):1702-12 |
All: |
2 reference(s) |
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