Tg(Myh6-Mef2d)2Eno
Transgene Detail

Summary

• Symbol: Tg(Myh6-Mef2d)2Eno
• Name: transgene insertion 2, Eric N Olson
• MGI ID: MGI:3776912
• Transgene: Tg(Myh6-Mef2d)2Eno Location: unknown
• Alliance: Tg(Myh6-Mef2d)2Eno page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Mef2d)2Eno expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Mef2d (MGI:99533)

• Mutation details: Mouse cDNA encoding FLAG-tagged mouse Mef2d was put under control of the mouse cardiac myosin heavy chain promoter. The construct also contains the human growth hormone polyA signal. Three transgenic lines were established (1, 2, and 3). Line 2 was more extensively characterized. Western blot analysis shows 15-fold higher levels of Mef2d expression compared to non-transgenic mice. (J:130825)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:130825 Kim Y, et al., The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest. 2008 Jan;118(1):124-32
• All: 1 reference(s)