Ovol2^tm1Sito
Targeted Allele Detail

Summary

• Symbol: Ovol2^tm1Sito
• Name: ovo like zinc finger 2; targeted mutation 1, Seiji Ito
• MGI ID: MGI:3777011
• Gene: Ovol2 Location: Chr2:144147095-144174000 bp, - strand Genetic Position: Chr2, 70.99 cM, cytoband H1
• Alliance: Ovol2^tm1Sito page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132526
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An frt-flanked neo cassette with a 3' loxP site was inserted downstream of exon 3 and an additional loxP site was inserted upsream of exon 3. Transient cre expression in ES cells was used to remove the neo cassette and exon 3. The absence of endogenous transcript expression was confirmed by RT-PCR. (J:132526)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ovol2 Mutation: 22 strains or lines available

Notes

This allele was derived by cre mediated recombination from Ovol2^tm2Sito

References

• Original: J:132526 Unezaki S, et al., Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice. Genes Cells. 2007 Jun;12(6):773-85
• All: 8 reference(s)