Crygb^S11R
Spontaneous Allele Detail

Summary

• Symbol: Crygb^S11R
• Name: crystallin, gamma B; S11R
• MGI ID: MGI:3777015
• Gene: Crygb Location: Chr1:65119381-65121449 bp, - strand Genetic Position: Chr1, 32.82 cM
• Alliance: Crygb^S11R page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Spontaneous
• Mutation: Single point mutation
• Mutation details: A T-to-G (A-to-C on negative gene strand) point mutation in codon 11 results in the substitution of serine with arginine at position 11 (p.S11R). (J:132502)
• Inheritance: Dominant

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Crygb Mutation: 15 strains or lines available

References

• Original: J:132502 Li L, et al., Dense nuclear cataract caused by the gammaB-crystallin S11R point mutation. Invest Ophthalmol Vis Sci. 2008 Jan;49(1):304-9
• All: 4 reference(s)