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Lrattm1.1Bok
Targeted Allele Detail
Summary
Symbol: Lrattm1.1Bok
Name: lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); targeted mutation 1.1, Dean Bok
MGI ID: MGI:3777017
Synonyms: LratL-
Gene: Lrat  Location: Chr3:82799889-82811281 bp, - strand  Genetic Position: Chr3, 36.81 cM
Alliance: Lrattm1.1Bok page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:132516
Parent Cell Line:  P1 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsLrattm1Bok mice were crossed with a Cre transgenic mouse that removed the floxed allele in the germline. Gene inactivation was confirmed by a lack of detectable protein in immunoblot analysis of various tissues and by immunohistochemical analysis of the retina. (J:132516)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Lrat Mutation:  26 strains or lines available
References
Original:  J:132516 Ruiz A, et al., Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5377-87
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory