Lrattm1.1Bok
Targeted Allele Detail
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Symbol: |
Lrattm1.1Bok |
Name: |
lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase); targeted mutation 1.1, Dean Bok |
MGI ID: |
MGI:3777017 |
Synonyms: |
LratL- |
Gene: |
Lrat Location: Chr3:82799889-82811281 bp, - strand Genetic Position: Chr3, 36.81 cM
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Alliance: |
Lrattm1.1Bok page
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Germline Transmission: |
Earliest citation of germline transmission:
J:132516
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Parent Cell Line: |
P1 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Lrattm1Bok mice were crossed with a Cre transgenic mouse that removed the floxed allele in the germline. Gene inactivation was confirmed by a lack of detectable protein in immunoblot analysis of various tissues and by immunohistochemical analysis of the retina.
(J:132516)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Lrat Mutation: |
26 strains or lines available
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Original: |
J:132516 Ruiz A, et al., Somatic ablation of the Lrat gene in the mouse retinal pigment epithelium drastically reduces its retinoid storage. Invest Ophthalmol Vis Sci. 2007 Dec;48(12):5377-87 |
All: |
4 reference(s) |
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