Hax1^tm1Jni
Targeted Allele Detail

Summary

• Symbol: Hax1^tm1Jni
• Name: HCLS1 associated X-1; targeted mutation 1, James N Ihle
• MGI ID: MGI:3777018
• Gene: Hax1 Location: Chr3:89902753-89906023 bp, - strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Hax1^tm1Jni page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:132627
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The coding region was replaced with a neo cassette. The absence of protein product was confirmed by western blot analysis on thymocyte extracts. (J:132627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hax1 Mutation: 36 strains or lines available

References

• Original: J:132627 Chao JR, et al., Hax1-mediated processing of HtrA2 by Parl allows survival of lymphocytes and neurons. Nature. 2008 Mar 6;452(7183):98-102
• All: 7 reference(s)